Target expansion potential to include EGFR and MET also confirmed
[by Yu, Suin] Abion revealed on April 29 the preclinical data on its TROP2-targeting antibody-interferon beta fusion protein, ‘ABN202,’ at the American Association for Cancer Research (AACR), highlighting its superior anticancer efficacy compared to existing commercialized antibody-drug conjugates (ADCs).
바카라사이트 홈런 is a therapeutic candidate consisting of an antibody targeting TROP2 antigen fused with interferon beta (IFN-β). In this study, 바카라사이트 홈런 demonstrated markedly improved anticancer efficacy compared to existing ADCs in various solid tumor models, including TROP2-positive breast cancer and non-small cell lung cancer (NSCLC).
Interferon beta is a type I interferon cytokine that plays a critical role in regulating immune responses and serves as a key mediator in activating immune mechanisms that induce 바카라사이트 홈런 cell removal.
바카라사이트 홈런 employs antibodies to specifically bind to antigens expressed on the surface of cancer cells, enabling the localized secretion of interferon beta to induce anticancer responses in target cancer cells. Unlike conventional ADCs that rely on cytotoxic payloads, 바카라사이트 홈런 harnesses interferon beta to activate a broad range of immune cells, thereby enhancing immune-mediated tumor destruction. This dual mechanism of action, direct targeting of cancer cells and immune system activation, confers a synergistic therapeutic effect.
"We have confirmed that 바카라사이트 홈런 maintains stable anticancer efficacy even in cases of cross-resistance among ADC therapies," a company official said. "Beyond TROP2, the platform has the potential to be expanded to target epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET)."
"It holds great value as a next-generation platform capable of complementing existing 바카라사이트 홈런, which face limitations in clinical application due to the toxicity associated with cytotoxic payloads," the official further noted.
The company is pursuing the establishment of a local subsidiary in the United States to initiate full-scale development of 바카라사이트 홈런. It aims to build an independent development framework by fostering collaborations and securing investment from U.S.-based biotechnology firms.